Edi-Set-Flow Report

EdiSetFlow Report

QC

Filtering

Coverage & rate

Sample summary table

Editing Summary

Base change distribution

Editing site consequences

Highly edited sites by VEP impact

Differential editing by group

Number of differentially edited sites

Differential editing Manhattan-style plot

Top differentially edited sites, 1000 per VEP impact

Marginal editing by group at top differential sites

PCA - Group and covariates

PCA table

Clustered heatmap at differential sites

Parameters

Parameter	Value
edisites	“edisites_shard_*.tsv.gz”
metadata	“manifest_9_regions_x50.csv”
output	“EdiSetFlow”
threads	32
fixed_effects	“sex,age”
model	“quasibinomial”
min_med_dp	10
min_med_vaf	0.001
max_med_vaf	1
adar_only	TRUE
grp_min_med_dp	10
grp_min_med_vaf	0.001
grp_max_med_vaf	0.999